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What should my health care professional know before I take Esomeprazole? Your doctor will tell you how long you will need to take Nexium, or you may require a dosage adjustment or special monitoring. If taken on an empty stomach at least one hour before a meal. There are no restrictions on food, beverages, or activities while taking Nexium, unless otherwise directed by your doctor. Your doctor will tell you how long you will need to take Nexium, or you may require a dosage adjustment or special monitoring. Because Nexium is likely to appear in breast milk you will need to choose between taking Nexium or breastfeeding your baby. Esomeprazole prevents symptoms and damage to the gastrointestinal tract caused by stomach acid or infection. Nexium is used to treat the infection, which is responsible for the majority of gastric ulcers. Nexium is usually taken once a day at least one hour before a meal.